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Friday, November 16, 2007

GTF & Diabetes (Trivalent Chromium)




GTF is short for glucose tolerance factor. GTF exists in all human tissues, and serves mainly to maintain the body’s normal sugar metabolism. Because it transports glucose into all cells in the body in coordination with insulin and insulin receptors, it is known as “glucose tolerance factor.” GTF must be present for insulin to activate insulin receptors. GTF is a complex material containing a core of trivalent chromium plus minerals, vitamin, and amino acids.

People normally obtain trivalent chromium from their food. This trivalent chromium is converted to GTF and helps maintain the normal metabolism of glucose. If a person suffers from a long-term shortage of trivalent chromium, their body will produce less GTF, and the glucose absorbed by their digestive system will not be taken into cells and converted to energy. Since highly concentrated blood sugar cannot be fully absorbed by the kidneys, the person will exhibit the clinical symptoms of diabetes, and the excess glucose will turn up in the urine. GTF plays an important role in the absorption of glucose by the kidneys:

Whenever the blood sugar concentration is higher than normal for a long period of time, there will be a large increase in GTF consumption as the body attempts to reabsorb excess glucose. GTF that has performed its function is excreted into the urine by the renal tubules, which severely depletes the body’s supply of trivalent chromium and causes the gradual loss of kidney function. This is one of the main reasons why diabetes occurs. Apart from this, overwork, pregnancy, obesity, old age, alcoholism, surgery, and disease may accelerate the loss of chromium from the body and worsen chromium deficiency. By making it harder for blood sugar to enter cells, chromium deficiency will induce the clinical symptoms of Type II diabetes.

At this website (http://www.gtf.com.my/eng/html/diabetes/about/about.htm) get more information on diabetes, namely :

1) What is diabetes
2) Types of diabetes
3) Symptoms
4) Diagnosis
5) How to control
6) What complications
7) Drugs for diabetes


What is GTF ?

GTF and Trivalent Chromiumns

Chromium is an element, which mostly exists in two oxidized forms, the hexavalent(Cr+6) and the trivalent(Cr+3). The former is poisonous and carcinogen, but the latter is non-poisonous and safe in mammal. Trivalent chromium is an essential nutrient. Chromium compounds are stable in the trivalent state, and occur in nature most commonly at this oxidation level. Hexavalent chromium compounds rarely occur in nature and are typically associated with industrial sources. Chromium in the diet exists as Cr+3.

Trivalent chromium compounds are commonly found is soil in most regions of the world. People obtained trivalent chromium by eating foods with natural concentrations derived from the soil. For the past half-century, modern agriculture has relied on chemical fertilizer, such as seasonal replenishment of nitrogen, potassium, and phosphorus. Over the years, the other naturally occurring essential minerals and trace elements, including chromium, have been exhausted in the soil and not replenished. Thus, most of our foods are chromium deficient at the level of agricultural production.

Food processing further reduces the chromium by as much as 90 percent. The result is widespread nutritional chromium deficiency of human body. Trivalent chromium is the most stable form and important in human glucose metabolism. Average dietary absorption ranges of chromium from 0.4% to 3%. Because most chromium compounds are soluble at the pH of the stomach, but less soluble hydroxides may form as pH is increased in intestine. And inorganic chromium easily undergoes olation with dietary fibers to form huge complex that will be very difficult to be absorbed by intestine.

So the organic forms of chromium as supplement are required to enhance the absorption rate of intestine. It is known that organic forms are absorbed at least 5 to 10 times more effectively than chromium chloride. As many as 90 percent of all American diets are low in chromium, because:

(1) soil depletion
(2) refined foods;
(3) excessive sugar consumption;
(4) lack of exercise; and
(5) obesity.

As a result, the diabetes rate has tripled since 1958 and now accounts for 15 percent of the nation's health care budget.

Relationship between GTF and Diabetes

Glucose Tolerance Factor (GTF) is sometimes also known as “insulin booster.” Insulin must interact with GTF and insulin receptor to successfully send glucose into cells so it can be converted to energy. GTF can therefore be said to boost the biological activity of insulin and enhance the insulin receptors’ sensitivity.

By promoting the binding of insulin and insulin receptors and increasing the permeability of the cell membrane, GTF enables blood sugar to enter cells.

GTF thus helps insulin accomplish its function of reducing blood sugar. As long as the elements of insulin, GTF, and insulin receptors are functioning properly, insulin can play its role as the body’s sole hormone responsible for reducing blood sugar. But if any one of these three elements is missing, hypoglycemia and diabetes will occur. Among diabetics, 5~10% lack insulin, roughly 10% lack insulin receptors, and the remaining 80% lack GTF. Most people with diabetes got that way mainly due to a lack of GTF.

Safety Taking of GTF

The purpose of taking GTF is to maintain healthy glucose, protein and lipid metabolism in our body. GTF is non-toxic. According to the evaluation report on USA Estimated Safe and Adequate Daily Dietary Intakes (US ESADDI) established by the US Environment Protection Agency, daily intake of chromium of not more than 350 times of the recommended dosage (200mcg) is within the safety limits. Safety limits of some other minerals, such as zinc, manganese, selenium etc, are only around 2 to 7 times of the daily intake.

According to a toxicity test report published by Anderson R. A. et. Al., after 20 weeks of feeding rats with does of chromium chloride equivalent to thousands times of human daily recommended intake, there is no evidence of toxification. This means that the safety dose of chromium chloride is several times of the ESADDI for humans. Also there is no evidence of toxic effects from supplemental chromium in the human studies. Therefore, GTF is a safe trace element for consumption as a supplement.



GTF (Glucose tolerance factor) is known as a hormone-like compound that works with insulin to transfer glucose from blood into cells. It is composed of certain trivalent chromium, some minerals, amino acids and vitamin. When GTF function is not working properly, the cells resist insulin and do not properly absorb the glucose needed for generation of energy. The liver also needs GTF to manufacture fatty acids, lecithin, cholesterol and lipoproteins. In 1959, Dr. Mertzs, the former director of the Institute of Human Nutrition, USDA, first discovered GTF in porcine kidney.

Later, researchers also found other types of GTF compounds in the liver of other animals, malt yeast and the colostrums of cattle. The best GTF is in human colostrums that are naturally designed for healthy growth in newborn infants. Many manufactures attempted to produce GTF but most production processes of GTF were unstable and could not be mass-produced for commercialization.

Maxluck Biotechnology Corp. have studied colostrums GTF for many years, we finally had a remarkable breakthrough and successfully manufactured colostrums GTF (brand name GT&F®). The GT&F® technology is a patented technology (USP 6,379,693) approved by USPTO. This biotechnological technique can mass produce GT&F®, instead of extracting colostrums GTF.

GT&F® Milk Powder is made by blending GT&F® with New Zealand best grade milk powder to mimic the bioactivity of colostrums GTF. Since GT&F® is non-toxic, does not produce side effects, contains no drugs, hormones, or toxins, it is safe to take. GT&F® is able to effectively promote functioning of insulin, and long-term use provides body with sufficient GTF to maintain homeostasis of blood sugar and also will prevent the occurrence of type 2 diabetes and its complications.

Directions :

1) GTF Milk Powder
...take a sachet a day (morning). You may increase to 02 a day)

2) GTF Capsule
...take 02 capsules a day (01 morning & 01 evening).


More important notes on the followings :

a) for healing processes of GTF Products (Milk Powder & Capsules Forms)
...(click below URL)
http://www.gtf.com.my/eng/html/product/healing/healing.htm

b) for testimonials : (click below) http://www.gtf.com.my/eng/html/product/testimonial/testimonial.htm

Market price (exclude delivery charges) :
1) GTF Milk Powder (30 sachets)
...RM 278 / SGD 128 / USD 85

2) GTF (60 capsules)
...RM 278 / SGD 128 / USD 85

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